Mirtazapine (generic Remeron®)
Mirtazapine is a prescription antidepressant that increases serotonin and norepinephrine in the brain. It’s used to treat depression symptoms and can help improve low mood and depressive thoughts.
- Get care from a real doctor, without leaving home
- Same-day prescriptions available
- Medication delivered free, straight to your door
Book a visit to meet with a QuickMD doctor for a mirtazapine prescription or refill
A QuickMD doctor can prescribe medication only after your visit, and prescriptions aren't guaranteed. The listed price covers medication only and doesn't include the cost of your doctor visit.
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Getting started with mirtazapine at QuickMD
Description
Mirtazapine is an FDA-approved medication used to treat major depressive disorder (MDD) in adults. Unlike SSRIs and SNRIs, it works by blocking certain receptors in the brain that normally limit the release of serotonin and norepinephrine, two chemicals that help regulate emotions and sleep. When used appropriately, patients may notice improvements not only in mood but also in sleep quality, appetite, and anxiety.
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Take mirtazapine by mouth, once a day, in the evening before sleep, at the same time each night, or as directed by your QuickMD doctor. You may take it with or without food. Mirtazapine is also available as an orally disintegrating tablet. Place it on your tongue and allow it to dissolve. No water is needed. Do not split the disintegrating tablet. Always use this medication exactly as prescribed by your doctor. Taking it at night is recommended, as its sedating effect can support sleep and tends to wear off by morning. Staying on schedule helps your body maintain consistent levels of the medication, which makes the treatment more effective. Each prescription comes with a patient information leaflet. Be sure to read it carefully, and ask your doctor if you have any questions.
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Mirtazapine may provide the following benefits:
- Improved mood and reduced feelings of sadness and emotional numbness
- Reduced anxiety and general sense of worry
- Earlier improvements in sleep compared to many other antidepressants
- Improved appetite and weight restoration in patients with depression-related weight loss
- Minimal nausea or gastrointestinal discomfort
Benefits and treatment outcomes vary from person to person.
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Serious or adverse side effects from mirtazapine are rare. However, some patients may experience:
- Drowsiness
- Increased appetite
- Dry mouth
- Weight gain
- Constipation
Contact your doctor right away if you experience signs of a serious allergic reaction (including DRESS, a rare multi-organ reaction involving fever, rash, and swollen glands), signs of serotonin syndrome (rapid heart rate, confusion, and muscle twitching), unusual bruising or infection, or worsening depression or thoughts of self-harm.
This is not a full list of side effects, interactions, or warnings, and it should not replace medical advice. For guidance tailored to your health and medications, always talk with your healthcare provider or pharmacist.
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Mirtazapine must be prescribed by a licensed doctor. Like any medication, mirtazapine comes with important safety considerations, including possible side effects, serious risks, and certain conditions where it may not be safe to use. A consultation with a QuickMD doctor is required to review your health and determine if this prescription medication is appropriate for you.
Mirtazapine may not be appropriate if you:
- Are taking or have recently taken an MAO inhibitor (such as phenelzine or selegiline)
- Are taking linezolid or methylene blue
- Have a known allergy or hypersensitivity to mirtazapine
- Have a history of low white blood cell count (neutropenia) or compromised immune function
- Have liver or kidney impairment, without close monitoring and dose adjustment
- Have a history of seizures or bipolar disorder, without first discussing risks with your doctor
- Are pregnant, planning to become pregnant, or breastfeeding, without first discussing risks with your doctor
This is not a complete list of precautions, contraindications, or drug interactions. Always talk with your healthcare provider or pharmacist about your medical history and any medications or supplements you are taking before starting mirtazapine.
Mirtazapine
Start feeling better mentally and emotionally. Meet with a QuickMD doctor and, if appropriate, receive a prescription for mirtazapine. No insurance required.
- Support your mental health with proven treatment
- Same-day prescriptions available after your visit
- Delivered straight to your door when prescribed
Medication price does not include the cost of your doctors visit.
Frequently asked
questions
Patients may notice a calming, sedating effect from mirtazapine within the very first dose, particularly at lower doses. This is due to its antihistamine properties, which can take effect quickly. However, the full antidepressant and anti-anxiety benefits may take two to four weeks to develop, with continued improvement over four to six weeks. It’s important to keep taking mirtazapine as prescribed during this time, even if the calming effect feels inconsistent at first. You will follow up with your QuickMD doctor to track your progress and adjust your dose if needed.
Weight gain is one of the more commonly reported side effects of mirtazapine, though individual outcomes vary from person to person. The medication increases appetite by blocking histamine receptors in the brain, which can make it easier to eat more without noticing. For patients whose depression has caused significant weight loss or suppressed appetite, this can be a therapeutic benefit. Your QuickMD doctor can help you decide this consideration against the overall benefits of treatment for your specific situation.
Mirtazapine and Xanax (alprazolam) are very different medications. Xanax is a benzodiazepine, which is a fast-acting sedative used for acute anxiety that carries a risk of dependence and is typically prescribed for short-term use. Mirtazapine is an antidepressant that builds its therapeutic effect gradually over several weeks and is intended for longer-term treatment of depression. While mirtazapine can have a calming and sedating quality, particularly at the start of treatment, it works through an entirely different mechanism and does not carry the same addiction risk as Xanax.
Start treatment with mirtazapine online
Book your first visit
Getting started begins with a simple online visit. You'll meet with a licensed QuickMD doctor from the comfort of home, where you can talk openly about what you've been going through and what kind of support you're looking for. The process is designed to feel comfortable, supportive, and pressure-free, so you can move forward with a clear understanding of what to expect and what comes next.
Learn more about mirtazapine
Your doctor will take time to understand any challenges you're facing, your mental health history, and what you've tried so far. If mirtazapine is appropriate, they'll guide you through how it works in your body, how to take it, what to expect, and how its calming, sleep-supportive effects can help you finally get the rest you need while your mood begins to stabilize. You'll leave your visit feeling informed and confident in your next steps.
Get your medication delivered
If your doctor prescribes mirtazapine, your prescription is sent directly to our pharmacy partner and shipped straight to your door. You'll receive clear instructions on how to take it, and your care doesn't stop there. Follow-up visits give your doctor a chance to check in on how you're responding, adjust your dose if needed, and make sure you're getting the support and relief you need.
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